Therapeutics

Antiviral Small Molecule Drug Discovery and Development Programs

Arenavirus

arenavirus Arenaviruses are transmitted to humans through infected rodents and contaminated materials. At least seven arenavirus species including Lassa Virus (LASV) can cause severe viral hemorrhagic fevers. Each year over 300,000 infections and 5000 deaths are associated with LASV alone. We are developing a lead series of novel broad-spectrum arenavirus cell entry inhibitors in association with the National Institute for Allergy and Infectious Disease (NIAID) (Grant R44AI112097).

Ebola

ebola Ebola viruses are endemic to regions of Africa and may be spread from human to human through transmission of bodily fluids. As witnessed in the 2014-2016 West African outbreak, which claimed over 11,000 lives, Ebola virus infection in humans is associated with severe hemorrhagic fever and high risk of mortality. Arisan is developing novel orally administered Ebola inhibitors for prophylactic and therapeutic treatment.
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