viruses are a rapidly evolving and highly diverse group of viruses associated with mild to severe disease symptoms. Annual seasonal outbreaks, typically spread through human to human contact, result in ~ 3-5 million cases of severe illness globally. More highly pathogenic strains of influenza, including H5N1 and H7N9 which remain primarily restricted to birds, exhibit lethality in ~ 30-50% of infected individuals. These viruses may evolve to spread through casual human contact. Arisan received support from NIAID (Grant R43AI106266) to develop novel broad-spectrum influenza A therapeutics.